If the sample size for a trial was calculated based on the following assumptions:

• Response rate Group A = 65%
• Response rate Group B = 50%
• Significance level 5%
• Power = 90%
• Objective to show a difference between treatment groups
  

Which of the following changes to the assumptions would result in the required sample size increasing?

1) Changing the Expected Response Rate in Group A to 68% while all other assumptions remain the same

2) Changing the Expected Response Rate in Group B to 48% while all other assumptions remain the same

3) Changing the Power Level to 80% while all other assumptions remain the same

Which of the following is correct