Challenge: Sample Sizing Clinical Trials
Question Number 1

Which of the following could potentially reduce the sample size requirement when designing a clinical trial?

  1. changing from a parallel group trial to a cross over trial
  2. making the entry criteria for the trial less variable
  3. increasing the power level
  4. changing the significance level from 5% to 1%
A
4 only
B
2 and 3 only
C
1 and 4 only
D
1 and 2 only

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